Dr. Jean Jacques Bonvent

Federal University of ABC, Brazil

Abstract Title: Development of nanostructured magnetic core-shell systems for controlled drug release

Biography: Jean Jacques Bonvent has completed his PhD from University of Bordeaux (CRPP) and postdoctoral studies from Philips NatLab, University of Calabria and University of São Paulo. He is associate professor at the federal university of ABC (Brazil) and has published more than 40 papers in peer-reviewed journals.

Research Interest: Drug Delivery Systems (DDS) can be engineered to specifically specific tissues, with release mechanisms triggered by physicochemical stimuli such as pH, temperature, or light irradiation, thereby minimizing undesirable side effects. To optimize the performance of DDS platforms, it is widely acknowledged that innovative strategies are essential for achieving precise control over parameters such as size, shape, porosity, and surface functionalization. In this study, we first describe the synthesis of mesoporous silica-coated magnetite nanoparticles (MNP@mSiO2) capped with polyelectrolytes (PE). The morphology and physical properties of the system's components were thoroughly characterized. Drug release experiments revealed that uncapped mesoporous silica nanoparticles loaded with TCH released over 90% of the drug within 48 hours, whereas the PE-capped nanoparticles released only 30%, attributed to the PE layer acting as a barrier to drug diffusion. In the second part of the study, we present preliminary findings on the microfluidic synthesis of functionalized mesoporous silica-coated magnetite nanoparticles, by a multistep approach that demonstrates enhanced control over tuning of these systems, highlighting its potential for advanced DDS applications.